Phosphorus oxide (P4O10) → Propanenitrile, 2,3,3,3-tetrafluoro-2-iodo-

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Reaction Conditions

Reaction Steps

2-Iodotetrafluoropropionamide prepared from Experiment 6 (16.3 g, 0.06 mol) was mixed well with P2O5 (16.3 g, 0.115 mol) in a flask under nitrogen atmosphere. The mixture was heated slowly to 95 to 100° C., a volatile product started to form and was collected in a cold trap (dry ice-acetone bath). The title product was obtained as a slightly pink liquid after purification by distillation, yield 12.5 g (82.5%), b.p. 68-70° C. 19F NMR (188.24 MHz, CDCl3): -78.7 (2 singlets, 3F), -137.9 (q, J =16 Hz, 1F); IR: 2288 cm-1 (C≡N); Mass. Calcd. for [M+ ]: 252.9382; Found: 252.9012.

Provenance & Evidence