Delta-Valerolactone → HCID 22116520, compound

Participants

Reaction Steps

Using a method similar to Example 1, valerolactone was reacted with 1,3-DAP. At a temperature of 170° C. in the liquid in the flask, 48% of the open-chain amide and 49% of 2-(4-hydroxybutyl)-1,3-diazacyclohex-1-ene were obtained after 8 hours. After a further 8 hours at 180° C. and 8 hours at a liquid-phase temperature of 190° C., the ratio shifted further to 5% of amide and 92% of 2-(4-hydroxybutyl)-1,3-diazacyclohex-1-ene. The subsequent product diazabicyclodecene was obtained in an amount of only 1 or 3%.

Provenance & Evidence