Phosgene → 2-Chloro-6-iodo-3-propyl-quinazolin-4-one

HRID 1276622Notes

Reaction equation

HRID 1276622 reaction equation
[I:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=S)[N:6]([CH2:13][CH2:14][CH3:15])[C:5]2=[O:16].C(Cl)([Cl:19])=O>>[Cl:19][C:7]1[N:6]([CH2:13][CH2:14][CH3:15])[C:5](=[O:16])[C:4]2[C:9](=[CH:10][CH:11]=[C:2]([I:1])[CH:3]=2)[N:8]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 108933556-iodo-3-propyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

Product 1

HCID 108610142-Chloro-6-iodo-3-propyl-quinazolin-4-one

Procedure

2,3-dihydro-6-iodo-3-propyl-2-thioxo-4(1H)-quinazolinone is reacted with phosgene to give 2-chloro-6-iodo-3-propyl-4(3H)-quinazolinone ; and

Sources & evidence

ORD record
ord-f04be63b61e24051b16d00493f43d62d
Source dataset
uspto-grants-2000_12
Patent number
US06166208

Reaction notes

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