Chloroacetyl chloride → HCID 22116589, compound

HRID 1276626Notes

Reaction equation

HRID 1276626 reaction equation
[NH2:1][CH:2]1[C:14]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[C:8]2[C:3]1=[CH:4][CH:5]=[CH:6][CH:7]=2.[Cl:15][CH2:16][C:17](Cl)=O.[NH:20]1[CH2:25][CH2:24][C:23]2([C:33]3[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=3)[CH2:27][O:26]2)[CH2:22][CH2:21]1>>[ClH:15].[CH:13]1[C:14]2[CH:2]([NH:1][CH2:16][CH2:17][N:20]3[CH2:25][CH2:24][C:23]4([C:33]5[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=5)[CH2:27][O:26]4)[CH2:22][CH2:21]3)[C:3]3[C:8](=[CH:7][CH:6]=[CH:5][CH:4]=3)[C:9]=2[CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 10671Fluoren-9-amineHCID 104424983H-spiro[2-benzofuran-1,4'-piperidine]

Product 1

HCID 22116589HCID 22116589, compound

Procedure

The title compound, m.p. 244° C. and MS: m/e=397.3 (M+H+), was prepared in accordance with the general method of example 1 from 9-amino-fluorene, chloroacetyl chloride, spiro[isobenzofuran-1(3H),4'-piperidine] and Hcl.

Sources & evidence

ORD record
ord-eead0eff6195457fb86b979d9f376174
Source dataset
uspto-grants-2000_12
Patent number
US06166209

Reaction notes

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