Borane → 1-Methyl-1,2-dihydrospiro[indole-3,4'-piperidine]

Participants

Reaction Steps

For the synthesis of the title compound, m.p. 222° C. and MS: m/e=437.4 (M+H+), 1-methyl-spiro[3H-indole-3,4'-piperidin]-2(1H)-one is reduced with borane according to example 16 to yield 1-methyl-1,2-dihydro-spiro[indole-3,4'-piperidine], which was further reacted with 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)-propan-3-ol in accordance with the general method of example 8.

Provenance & Evidence