Hydrogen Peroxide → 4-Piperidinol, 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethyl-

Participants

Reaction Conditions

Reaction Steps

A solution of 9.4 g (140 mmol) of 50% aqueous hydrogen peroxide mixed with 20 mL of tert-butyl alcohol is added over four hours at 45-50° C. to a mixture of 3.44 g (20.0 mmol) of 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine, 0.125 g (0.77 mmol) of anhydrous ferric chloride, 30 mL of tert-butyl alcohol and 10 mL of water. The temperature is then maintained at 45-50° C. for 19 hours. Analysis by gas chromatography shows less than 1% of the starting nitroxyl compound is present.

Provenance & Evidence