Hydrogen Peroxide → 4-Piperidinol, 1-(2-hydroxy-2-methylpropoxy)-2,2,6,6-tetramethyl-

Participants

Reaction Conditions

Reaction Steps

A solution of 50% aqueous hydrogen peroxide is added at a rate of approximately 100 mmol per hour and, simultaneously, a solution of 17.2 g (100 mmol) of 4-hydroxy-1-oxyl-2,2,6,6-tetramethylpiperidine dissolved in 40-45 mL of water is added at a rate of 35-50mmol per hour to a mixture of metal salt, acid if used, 25 mL of water and 200 mL of tert-butyl alcohol maintained at 35-45° C. The reaction mixture is maintained at 35-45° C. after all reactants are added, and in some cases the reaction mixture is stirred overnight at room temperature. The reaction is monitored by gas chromatography. Results are tabulated below.

Provenance & Evidence