Trifluoroacetic anhydride → HCID 12039968, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the compound of Example 260 (0.6 g) and Nal (0.8 g) in 10 mL acetone was added slowly 0.4 mL trifluoroacetic anhydride at 0° C. and the mixture was stirred at 0° C. for an additional hour. Then CH2Cl2 and aq sat sodium meta-bisulfite were added. The organic layer was separated, washed with brine, dried and concentrated. Flash chromatography of the residue with 10% ethyl acetate-hexane gave 0.5 g of the title compound as a white solid. m.p. 58-61° C.

Provenance & Evidence