Sodium Hydroxide → HCID 22116787, compound

HRID 1276828Notes

Reaction equation

HRID 1276828 reaction equation
F[C:2]1[C:10]([F:11])=[C:9]([F:12])[C:8]([F:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-:14].[Na+]>CN1CCN(C)C1=O>[F:11][C:10]1[C:9]([F:12])=[C:8]([F:13])[CH:7]=[C:3]([C:4]([OH:6])=[O:5])[C:2]=1[OH:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 2975492,3,4,5-Tetrafluorobenzoic acid

Product 1

HCID 22116787HCID 22116787, compoundYield 29.7%

Reagents, catalysts & solvents 1

HCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Conditions

Temperature
130 °C

Procedure

3.88 g (0.02 mole) of 2,3,4,5-tetrafluorobenzoic acid, 3.23 g (0.08 mole) of powdery 99% sodium hydroxide and 40 ml of 1,3-dimethyl-2-imidazolidinone were fed into a 200-ml four-necked flask provided with a thermometer, a stirrer and a reflux condenser. The mixture was stirred at 130° C. for 3 hours to give rise to a reaction. Then, the same post-treatment as in Example 1 was conducted to obtain 1.14 g of 3,4,5-trifluorosalicylic acid. The isolated yield was 29.7% relative to the 2,3,4,5-tetrafluorobenzoic acid used.

Workup

  1. customprovided with a thermometer, a stirrer and a reflux condenser
  2. customto give rise
  3. customto a reaction

Sources & evidence

ORD record
ord-ec383d392b9542e6916c944cc63d204b
Source dataset
uspto-grants-2000_12
Patent number
US06166246

Reaction notes

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