5-Fluorouracil → Tegafur

Participants

Reaction Steps

In 20 ml of dimethylformamide were dissolved 1.3 g of 5-fluorouracil. To this solution were added 1.4 g of 2,3-dihydrofuran and the mixture was reacted in an autoclave for 5 hours at 170° C. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 1 whereby 0.35 g of the starting 5-fluorouracil was recovered as a substance insoluble in chloroform and 1.20 g of 1-(2-tetrahydrofuryl)-5-fluorouracil were obtained. The yield of the end product was 82% based on the consumed 5-fluorouracil.

Provenance & Evidence