Triethylamine → HCID 12042347, compound

Participants

Reaction Steps

1-(2-Chlorobenzyl)-2-n-propylbenzimidazole (150 mg) and 61 mg of triethylamine were dissolved in 3 ml of methylene chloride, and 70 mg of methanesulfonyl chloride were added thereto at room temperature. The mixture was stirred for 1 hour, then washed with dilute hydrochloric acid, washed with water, and dried. The solvent was distilled off under reduced pressure. The residual solid was collected with ether through filtration to give 124 mg of 1-(2-chlorobenzyl)-6-mesylamino-2-n-propylbenzimidazole (88).

Provenance & Evidence