Hydrochloric Acid → HCID 54561726, compound

Participants

Reaction Steps

The above-mentioned crude methyl 1-(2-chlorobenzyl)-2-methylbenzimidazole-6-acrylate (3.29 g) was dissolved in 20 ml of ethanol, and 10.1 g of a 5% sodium hydroxide aqueous solution were added thereto. The mixture was refluxed for 2 hours. The reaction solution was neutralized with a hydrochloric acid aqueous solution. The solvent was distilled off under reduced pressure, and the residue was purified through silica-gel chromatography (eluent: a mixture of chloroform and methanol at a ratio of from 9:1 to 6:1) to give 1.10 g of 1-(2-chlorobenzyl)-2-methylbenzimidazole-6-acrylic acid.

Provenance & Evidence