反应详情

A mixture of 6.00 g of 3-fluoro-4-methylbiphenyl, 5.73 g of N-bromosuccinimide, 0.075 g of 2,2'-azobisisobutylonitrile and 120 ml of carbon tetrachloride was heat-refluxed for 5 hours. The reaction solution was washed with water, and the organic layer was concentrated. The resulting residue was purified through silica-gel column chromatography (eluent: a mixture of hexane and ethyl acetate at a ratio of 9:1) to give 8.30 g of oily 4-bromomethyl-3-fluorobiphenyl.

1. temperaturewas heat-refluxed for 5 hours
2. washThe reaction solution was washed with water
3. concentrationthe organic layer was concentrated
4. customThe resulting residue was purified through silica-gel column chromatography (eluent
5. additiona mixture of hexane and ethyl acetate at a ratio of 9:1)