5-Fluorouracil → Tegafur

Participants

Reaction Steps

In 50 ml of pyridine were dissolved 2.5 g of 5-fluorouracil and 0.64 g of ferric chloride. The reaction was carried out at 120° C. for 8 hours while adding 2.3 ml of 2,3-dihydrofuran to the solution. The reaction liquid was treated in the same manner as described in Example 12 to obtain 1.8 g of 1-(2-tetrahydrofuryl)-5-fluorouracil. From the aqueous layer 0.8 g of unreacted 5-fluorouracil was recovered. The yield of the end product was 69% based on the consumed 5-fluorouracil.

Provenance & Evidence