反应详情

Methylethylamine, 0.71 ml (8.32 mmole) and 2.46 ml (8.32 mmole) Ti(OPr)4 were dissolved in 17 ml of ethanol and stirred for 10 minutes under nitrogen. Compound of step D, 1.75 g (4.16 mmole), was added and the mixture was stirred for 4 hours. Sodium borohydride, 240 mg (6.23 mmole) was added and the reaction was stirred for 3 days. Asponia, 5.8 ml 2N, was added to give a thick suspension. Methylene chloride (40 ml) was added then 5.3 g diatomaceous earth and the mixture was stirred, and filtered through diatomaceous earth. The filtrate was washed 2 times with brine then dried. The organics were stripped and chromatographed, eluting with methylene chloride/methanol/concentrated ammonia 90:10:1. Fractions were bulked, stripped, dissolved in methylene chloride/isopropyl ether. Hydrogen chloride gas was bubbled in. Product was evaporate to dryness to give 1.36 g (63%) of a white foam.

1. stirringthe mixture was stirred for 4 hours
2. stirringthe reaction was stirred for 3 days
3. additionAsponia, 5.8 ml 2N, was added
4. customto give a thick suspension
5. stirring5.3 g diatomaceous earth and the mixture was stirred
6. filtrationfiltered through diatomaceous earth
7. washThe filtrate was washed 2 times with brine
8. customthen dried
9. customchromatographed
10. washeluting with methylene chloride/methanol/concentrated ammonia 90:10:1
11. dissolutiondissolved in methylene chloride/isopropyl ether
12. customHydrogen chloride gas was bubbled in
13. customProduct was evaporate to dryness