Glycine → Tegafur

Participants

Reaction Conditions

Reaction Steps

In 20 ml of dimethylformamide were dissolved 1.3 g of 5-fluorouracil and 0.75 g of glycin. 2.8 Grams of 2,3-dihydrofuran in several portions were added in 8 hours to the solution while heating it at 145° C. The mixture was then reacted for 5 hours at the same temperature. After completion of the reaction, the reaction liquid was treated in the same manner as described in Example 16. 0.9 g of 1-(2-tetrahydrofuryl)-5-fluorouracil was obtained and 1.0 g of 5-fluorouracil containing 0.75 g of glycin was recovered. The yield of the end product was 56% based on the consumed 5-fluorouracil.

Provenance & Evidence