反应详情

In ethanol (100 ml) was dissolved 1-(4-nitrobenzyl)-pyrrolidine (23.5 g), and to the mixture was added dried 10% palladium on carbon (1.00 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 20 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate/triethylamine=10/1) to give 1-(4-aminobenzyl)pyrrolidine (8.54 g) as orange oil.

1. additionto the mixture was added
2. dry with materialdried 10% palladium on carbon (1.00 g)
3. filtrationThe palladium was filtered off
4. concentrationthe filtrate was concentrated
5. customThe residue was separated
6. custompurified with column chromatography (ethyl acetate/triethylamine=10/1)