Acetic Anhydride → 1-Acetyl-3,5-dipyrazinyl-1,2,4-triazole

HRID 127704Notes

Reaction equation

HRID 127704 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]1[N:11]=[C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)[NH:9][N:8]=1.[C:18](OC(=O)C)(=[O:20])[CH3:19]>>[C:18]([N:8]1[C:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[N:11][C:10]([C:12]2[CH:17]=[N:16][CH:15]=[CH:14][N:13]=2)=[N:9]1)(=[O:20])[CH3:19]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 135247872-(5-pyrazin-2-yl-4H-1,2,4-triazol-3-yl)pyrazine

Product 1

HCID 202858161-Acetyl-3,5-dipyrazinyl-1,2,4-triazole

Procedure

A suspension of 3,5-dipyrazinyl-1,2,4-triazole (0.5 grams) in 20 ml. of acetic anhydride is heated on a steam bath for 17 hours. The resulting solution is filtered and concentrated to a solid. After recrystallization from benzene-hexane, 250 mg. of 1-acetyl-3,5-dipyrazinyl-1,2,4-triazole is obtained, m.p. 128°-130° C.

Workup

  1. filtrationThe resulting solution is filtered
  2. concentrationconcentrated to a solid
  3. customAfter recrystallization from benzene-hexane, 250 mg

Sources & evidence

ORD record
ord-e782d527207e4cc6b6c85d86af5b416f
Source dataset
uspto-grants-1981_03
Patent number
US04256887

Reaction notes

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