HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Isoxazolamine, 5-(1,1-dimethylethyl)- | HCID 171473 | 124.4% |
Reaction Steps
A suspension of pivaloylacetonitrile (12.52 g), sodium carbonate (8.74 g) and water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g) at 25° C. pH 7.11. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (12.01 g). Yield, 85.7%. Purity, 95.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04256899 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-fb681df70af54e46886ea03fbdfbd7f2 |
| Source note | uspto-grants-1981_03 |