HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Isoxazolamine, 5-(1,1-dimethylethyl)- | HCID 171473 | 81.7% |
Reaction Steps
A suspension of pivaloylacetonitrile (12.52 g) and triethylamine (11.27 g) in water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g). pH 8.22. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (11.45 g; yield, 81.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04256899 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-d73c023895844ceaa0b5ec960b928bde |
| Source note | uspto-grants-1981_03 |