HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| Reactant | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Isoxazolamine, 5-(1,1-dimethylethyl)- | HCID 171473 | 124.7% |
Reaction Steps
To a suspension of pivaloylacetonitrile (1.252 g) and 86% potassium hydroxide (0.717 g) in water (20 ml) is added hydroxylamine sulfate (0.903 g) at 25° C. and the mixture is stirred for 3 minutes. pH 8.30. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (1.204 g). Yield, 85.9%. Purity, 95.8%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04256899 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-26f5c1e9929c44e3ac1479cd52b74e18 |
| Source note | uspto-grants-1981_03 |