Hydrochloric Acid → 3-(5-p-Tolyl-furan-2-yl)-acrylic acid

Participants

Reaction Steps

To a solution of methyl (E)-3-[5-(4-methylphenyl)-furan-2-yl]acrylate (1.49 g) in tetrahydrofuran-ethanol (10-10 ml) was added 2N sodium hydroxide (4 ml) at room temperature, and the mixture was stirred for 24 hours. The reaction mixture was acidified with 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with magnesium sulfate and concentrated under reduced pressure to give (E)-3-[5-(4-methylphenyl)-furan-2-yl]acrylic acid (0.93 g) as colorless crystals.

Provenance & Evidence