2-Amino-5-bromobenzenemethanol → 2-Amino-5-bromobenzaldehyde

HRID 1277314Notes

Reaction equation

HRID 1277314 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH2:9][OH:10]>[O-2].[O-2].[Mn+4].CC(C)=O>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][C:3]=1[CH:9]=[O:10]

Participants

4

Reactant 1

HCID 110308742-Amino-5-bromobenzenemethanol

Product 1

HCID 235104752-Amino-5-bromobenzaldehydeYield 71.1%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

To acetone (300 ml) were added (2-amino-5-bromophenyl)methanol (23.32 g) and active manganese dioxide (58.5 g), and the mixture was stirred at room temperature for 17.5 hours and filtered. The solvent was evaporated under reduced pressure to give 2-amino-5-bromobenzaldehyde (16.41 g, 71%).

Workup

  1. filtrationfiltered
  2. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-20e0091c271a4d64a8a68a5ee5aab544
Source dataset
uspto-grants-2000_12
Patent number
US06166006

Reaction notes

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