HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanolamine → [2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | 1,4-Dioxane-2,6-dione | HCID 78232 | — |
| Reactant | Methanesulfonate | HCID 85257 | — |
| Product | [2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid | HCID 20558836 | — |
Reaction Steps
methanesulfonate by (a) reacting diglycolic anhydride and 2-aminoethanol to produce [2-(2-hydroxyethylamino)-2-oxoethoxy]acetic acid, (b) heating to cyclixe the latter to obtain 4-(2-hydroxyethyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 2-(3,5-dioxomorpholino)ethyl methanesulfonate and (d) reacting the mesylate with piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04256891 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-69a71491bb6d4704857d6737cffbdffb |
| Source note | uspto-grants-1981_03 |