Sodium Hydroxide → HCID 23453513, compound

HRID 1277338Notes

Reaction equation

HRID 1277338 reaction equation
C([O:3][C:4](=[O:26])[CH:5]([CH2:19]C1C=CC=CC=1)[CH:6]([C:11]1([CH:17]=[O:18])[S:16][CH2:15][CH2:14][CH2:13][S:12]1)[C:7]([F:10])([F:9])[F:8])C.[OH-].[Na+]>>[CH:17]([C:11]1([CH:6]([C:7]([F:8])([F:9])[F:10])[CH:5]([CH3:19])[C:4]([OH:26])=[O:3])[S:12][CH2:13][CH2:14][CH2:15][S:16]1)=[O:18]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 54435008HCID 54435008, compound

Product 1

HCID 23453513HCID 23453513, compound

Procedure

A solution of 3 g of the ethyl ester of Example 2, paragraph 1, in 40 ml ofethanol is treated with 25% aqueous sodium hydroxide for about 15 hours at 25° C. The mixture is then acidified and extracted well with chloroform. The organic phase is dried and concentrated to afford the title compound.

Workup

  1. extractionextracted well with chloroform
  2. customThe organic phase is dried
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-91af131f3f3a470db763f62b137a7329
Source dataset
uspto-grants-1981_07
Patent number
US04277395

Reaction notes

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