HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → HCID 86737835, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | HCID 54517210 | HCID 54517210 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86737835 | HCID 86737835 | — |
Reaction Steps
A solution of 462 mg (2 mMole) of the product of Example 4 in 20 ml of tetrahydrofuran is treated with 524 mg (2 mMole) of triphenylphosphine, 268 mg (2 mMole) of phthalimide, and 350 mg (2 mMole) of diethyl azodicarboxylate for 48 hours at 25° C. The solvent is evaporated and the product isolated by chromatography on silica gel affording 3-[2-(1-phthalimidoethyl)-1,3-dithian-2-yl]-4,4,4-trifluoro-2-methylbutyric acid methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04277395 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-0b2ae62d9736441da9e1d50e882adf3a |
| Source note | uspto-grants-1981_07 |