Sodium borohydride → HCID 56627995, compound

HRID 1277358Notes

Reaction equation

HRID 1277358 reaction equation
[N:1]1([C:6](=[CH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])[C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[O:8])[CH:5]=[N:4][CH:3]=[N:2]1.[BH4-].[Na+]>CO>[N:1]1([C:6](=[CH:16][C:17](=[O:22])[C:18]([CH3:20])([CH3:19])[CH3:21])[CH:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[OH:8])[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 53816685HCID 53816685, compound

Product 1

HCID 56627995HCID 56627995, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

The product (6.4 g, 0.02 mol) of Stage 2 was dissolved in methanol(100 ml) and to this solution was added sodium borohydride (0.2 g, 0.005 mol) at 0°. After stirring at room temperature for 15 hours the methanol was removed in vacuo. The residue was washed with water and neutralised with dilute hydrochloric acid. Recrystallisation of the solid from petroleum ether/ethanol gave the title compound as white needles, m.p. 156°-160°.

Workup

  1. customwas removed in vacuo
  2. washThe residue was washed with water and neutralised with dilute hydrochloric acid
  3. customRecrystallisation of the solid from petroleum ether/ethanol

Sources & evidence

ORD record
ord-38618d3ff2994abd9f9e32c3b4f17070
Source dataset
uspto-grants-1981_07
Patent number
US04277469

Reaction notes

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