HCID 23453689, compound → HCID 23453708, compound

HRID 1277359Notes

Reaction equation

HRID 1277359 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[CH:14]2[CH2:15][CH:11]([CH:12]=[CH:13]2)[C:10]1([CH2:19][CH2:20][C:21]([O:23]C)=O)[N+:16]([O-])=O>C(O)C.[Ni]>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[C:10]2([CH2:19][CH2:20][C:21](=[O:23])[NH:16]2)[CH:11]2[CH2:15][CH:14]1[CH2:13][CH2:12]2

Participants

4

Reactant 1

HCID 23453689HCID 23453689, compound

Product 1

HCID 23453708HCID 23453708, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

0.2 mole of methyl β-[3-(2-methoxyphenyl)-2-nitrobicyclo[2.2.1]-hept-5-en-2-yl]-propionate is dissolved in 800 ml of ethanol and, after adding 2 spatulas of Raney nickel, is hydrogenated at 50° C. and under 70 bars for 24 hours. The catalyst is filtered off, the solvent is evaporated off in a rotary evaporator and the residue is recrystallized from isopropanol. Colorless crystals of melting point 260° C.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solvent is evaporated off in a rotary evaporator
  3. customthe residue is recrystallized from isopropanol

Sources & evidence

ORD record
ord-905375d59e9c4a528bebe6630bd18043
Source dataset
uspto-grants-1981_07
Patent number
US04277470

Reaction notes

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