HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 70569239, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Fumaric Acid | HCID 444972 | — |
| Reactant | HCID 86737838 | HCID 86737838 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 70569239 | HCID 70569239 | — |
Reaction Steps
50 mmoles of 5'-methylthio-3-phenyl-spiro[bicyclo[2.2.1]-heptane-2,2'-5-pyrroline] hydriodide are treated with 250 ml of aqueous ammonia at 70° C. andunder a nitrogen pressure of 80 bars for 24 hours. After stripping off the solvent, an oil which slowly solidifies is obtained. After conversion intothe addition salt of fumaric acid, colorless crystals of melting point 242° C. (from methanol/water 1:1) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04277470 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-73d7d22800fc4cfc9f9a570f248b3895 |
| Source note | uspto-grants-1981_07 |