反应详情

186.8 g of pseudo-pelletierine and 264 g of freshly distilled chloroformic acid ethyl ester are slowly heated to a boil in 1 liter of absolute toluene within one hour. A vigorous evolution of gas sets in. The mixture is heated to a boil under reflux for a further 16 hours, then cooled and filtered. The filtrate is concentrated in a vacuum, and the residue is purified through vacuum distillation to obtain 223 g (86.5 percent) of light-yellow oil (b.p. 101° C. at 2.7 Pa.)

1. temperatureThe mixture is heated to a boil
2. temperatureunder reflux for a further 16 hours
3. temperaturecooled
4. filtrationfiltered
5. concentrationThe filtrate is concentrated in a vacuum
6. distillationthe residue is purified through vacuum distillation