HCID 12802504, compound → HCID 12802506, compound

HRID 1277389Notes

Reaction equation

HRID 1277389 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:11]([NH:13][C@@H:14]([C:19]([NH:21][CH2:22][C:23]([NH:25][C@H:26]([C:34]([NH:36][NH:37][C:38]([CH3:40])=[O:39])=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:24])=[O:20])[CH2:15][CH:16]([CH3:18])[CH3:17])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1>CO.[Pd]>[NH2:1][C@H:2]([C:11]([NH:13][C@@H:14]([C:19]([NH:21][CH2:22][C:23]([NH:25][C@H:26]([C:34]([NH:36][NH:37][C:38]([CH3:40])=[O:39])=[O:35])[CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:24])=[O:20])[CH2:15][CH:16]([CH3:17])[CH3:18])=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1

Participants

4

Reactant 1

HCID 12802504HCID 12802504, compound

Product 1

HCID 12802506HCID 12802506, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

In 50 ml of MeOH is dissolved 500 ml of Z-Tyr-(D)-Leu-Gly-Phe-NH-NH-CO-CH3, and following addition of 1 ml ofacetic acid, catalytic reduction is carried out with palladium black as thecatalyst. The catalyst is filtered off, the solvent is distilled off, the residue is treated with water and the insolubles are filtered off. The filtrate is lyophilized and the resulting powders are put on a column of Sephadex LH-20 (2.5×120 cm).

Workup

  1. filtrationThe catalyst is filtered off
  2. distillationthe solvent is distilled off
  3. additionthe residue is treated with water
  4. filtrationthe insolubles are filtered off

Sources & evidence

ORD record
ord-a11ec136f8aa42be917462e45dc25282
Source dataset
uspto-grants-1981_07
Patent number
US04277394

Reaction notes

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