Sodium Hydroxide → HCID 178460323, compound

HRID 1277406Notes

Reaction equation

HRID 1277406 reaction equation
[NH:1]([C:42]([O:44][C:45]([CH3:48])([CH3:47])[CH3:46])=[O:43])[C@@H:2]([C:19]([NH:21][CH2:22][C:23]([NH:25][C@H](C(NNC(CC)=O)=O)CC1C=CC=CC=1)=[O:24])=[O:20])[CH2:3][C:4]1[N:8]=[CH:7][N:6](S(C2C=CC(C)=CC=2)(=O)=O)[CH:5]=1.[OH-:49].[Na+]>CO>[NH:1]([C:42]([O:44][C:45]([CH3:46])([CH3:47])[CH3:48])=[O:43])[C@@H:2]([C:19]([NH:21][CH2:22][C:23]([NH:25][NH:1][C:2]([CH2:3][CH3:4])=[O:49])=[O:24])=[O:20])[CH2:3][C:4]1[N:8]=[CH:7][NH:6][CH:5]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12802560HCID 12802560, compound

Product 1

HCID 178460323HCID 178460323, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

BOC-(D)-His(Tos)-Gly-Phe-NHNH-COCH2CH3 (0.55 g) is suspended in MeOH (15 ml) and to this is added 1 N-sodium hydroxide solution (1 ml) at 0° C. The mixture is stirred for 60 min. at room temperature and evaporated. The residue is treated with acetonitrile to give a powder, which is washed with water and dried; yield 0.29 g. m.p. 261°-263° C., [α]D23 +9.5°(c=0.40, DMF), Rf2 =0.38

Workup

  1. customevaporated
  2. additionThe residue is treated with acetonitrile
  3. customto give a powder, which
  4. washis washed with water
  5. customdried

Sources & evidence

ORD record
ord-2a97f01602744d41932d494e8764525d
Source dataset
uspto-grants-1981_07
Patent number
US04277394

Reaction notes

Loading…