HCID 131712286, compound → HCID 178460322, compound

HRID 1277407Notes

Reaction equation

HRID 1277407 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:11]([NH:13][C@@H:14]([C:21]([NH:23][CH2:24][C:25]([NH:27][C@H:28]([C:36]([NH:38][NH:39][C:40]([CH2:42][CH3:43])=[O:41])=[O:37])[CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:26])=[O:22])[CH2:15][C:16]1[N:20]=[CH:19][NH:18][CH:17]=1)=[O:12])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1.N(C(OCC1C=CC=CC=1)=O)[C@H](C(N[C@@H](C(NCC(O)=O)=O)[C@H](C)O)=O)CC1C=CC(O)=CC=1>>[NH2:1][C@H:2]([C:11]([NH:13][C@@H:14]([C:21]([NH:23][CH2:24][C:25]([NH:27][C@H:28]([C:36]([NH:38][NH:39][C:40]([CH2:42][CH3:43])=[O:41])=[O:37])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1)=[O:26])=[O:22])[CH2:15][C:16]1[N:20]=[CH:19][NH:18][CH:17]=1)=[O:12])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([OH:10])=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 131712286HCID 131712286, compoundHCID 178460321HCID 178460321, compound

Product 1

HCID 178460322HCID 178460322, compoundYield 55.2%

Procedure

Using Z-Tyr-(D)-His-Gly-Phe-NHNH-COCH2CH3 (0.20 g), the desired compound (90 mg) is obtained in a similar manner to (II) of Example 4.Rf2 =0.15, Amino acid analysis His 0.95, Gly 1.00, Tyr 0.85, Phe 1.02

Sources & evidence

ORD record
ord-604f2fe9fc774314a9317051e7fa6419
Source dataset
uspto-grants-1981_07
Patent number
US04277394

Reaction notes

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