HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-(((tert-butoxy)carbonyl)amino)-4-methanesulfonylbutanoic acid → BOC-(D)-Met(O2)-Gly-Phe-NHNH-COCH3
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-(((tert-butoxy)carbonyl)amino)-4-methanesulfonylbutanoic acid | HCID 12802585 | — |
| Reactant | H-Gly-Phe-NHNH-COCH3 | HCID 131712285 | — |
| Product | BOC-(D)-Met(O2)-Gly-Phe-NHNH-COCH3 | HCID 12802564 | 52.7% |
Reaction Steps
Using H-Gly-Phe-NHNH-COCH3 (0.69 g) and BOC-(D)-Met(O2)-OH (0.66 g), the desired compound (0.67 g) is obtained in a similar manner to (III)of Example 45. m.p. 198°-199° C.(decomp.), [α]D23 -2.5°(c=0.49, DMF), Rf1 =0.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04277394 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-7fb8955299554cc8bef35aa8019720c5 |
| Source note | uspto-grants-1981_07 |