Thionyl Chloride → HCID 20475927, compound

HRID 1277432Notes

Reaction equation

HRID 1277432 reaction equation
S(Cl)([Cl:3])=O.[CH3:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH:16](O)[CH2:17][N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1)[CH:10]=[CH:9]2>>[ClH:3].[CH3:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH:16]([Cl:3])[CH2:17][N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1)[CH:10]=[CH:9]2

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 20475913HCID 20475913, compound

Product 1

HCID 20475927HCID 20475927, compound

Procedure

Thionyl chloride (5 ml.) and 2.0 g. of 1-[2-(6-methyl-2-naphthyl)-2-hydroxyethyl]imidazole are stirred at room temperature for about 20 minutes. Thereafter, the solution is evaporated to dryness and the residue is treated with ethyl acetate and filtered to yield 1-[2-(6-methyl-2-naphthyl)-2-chloroethyl]imidazole hydrochloride.

Workup

  1. customThereafter, the solution is evaporated to dryness
  2. additionthe residue is treated with ethyl acetate
  3. filtrationfiltered

Sources & evidence

ORD record
ord-d7d0575275064f4db4a742ee64b0bbcd
Source dataset
uspto-grants-1981_07
Patent number
US04277486

Reaction notes

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