2-(3-Phthalimidopropylthio)oxazole → 2-(3-Aminopropyl)thiooxazole

Participants

Reaction Steps

Hydrazine hydride (5.3 g) was added carefully to a solution of 2-(3-phthalimidopropylthio)oxazole (10 g) in ethanol (173 ml) with stirring. The solution was then heated under reflux for 25 minutes. After cooling, and filtration from phthalhydrazide, the filtrate was concentrated under reduced pressure and the residue was re-evaporated withethanol to yield crude 2-(3-aminopropylthio)oxazole.

Provenance & Evidence