反应详情

By processes similar to those described in Examples 1, 2 and 3, phthalimidoacetonitrile (27.9 g.) was caused to react with 1-methylcycloheptan-1-ol (24 g.) in glacial acetic acid solution (90 ml.) at 50° C. by the addition of concentrated sulphuric acid (0 ml.). After the initial vigorous reaction, a further 6 ml. of sulphuric acid wasadded. After 2 hours the resulting N-(1-methylcycloheptyl)-2-phthalimidoacetamide was isolated by pouring into water; it was collected, washed and dried before crystallisation frombenzene; it was obtained as a colourless crystalline solid, m.p. 190° C.

1. customAfter the initial vigorous reaction