反应详情

温度

-50 °C

A solution of chloroacetonitrile (15.1 g., 0.2 mol) and 2-methylheptan-2-ol (26.0 g., 0.2 mol) in acetic acid (120 ml) was treatedwith concentrated sulphuric acid (24 ml) with the temperature maintained at40°-50° C. After stirring for 1/2 hour the mixture was pouredinto ice-water (500 ml) and extracted with ether (3×400 ml). The combined extracts were washed with aqueous sodium carbonate until neutral and then evaporated to give 2-chloro-N-(1,1-dimethylhexyl)acetamide as a colourless solid m.p. 36°-37° C., b.p. 60°-62°C. at 0.01 mm Hg.

1. extractionextracted with ether (3×400 ml)
2. washThe combined extracts were washed with aqueous sodium carbonate until neutral and
3. customthen evaporated