Benzylamine → 2-benzylamino-N-(1,1-dimethylhexyl)acetamide

HRID 1277489Notes

Reaction equation

HRID 1277489 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:10][C:11]([NH:13][C:14]([CH3:21])([CH3:20])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:12]>C1C=CC=CC=1>[CH2:1]([NH:8][CH2:10][C:11]([NH:13][C:14]([CH3:20])([CH3:21])[CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 234541292-chloro-N-(1,1-dimethylhexyl)acetamide

Product 1

HCID 234541542-benzylamino-N-(1,1-dimethylhexyl)acetamide

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of benzylamine (21.4 g, 0.2 mol) and 2-chloro-N-(1,1-dimethylhexyl)acetamide (20.6 g, 0.1 mol) in benzene (100 ml) was held at room temperature for five days then refluxed for 24 hours.The mixture was filtered and the filtrate was evaporated then distilled under reduced pressure to give 2-benzylamino-N-(1,1-dimethylhexyl)acetamide as a pale yellow oil, b.p. 153°-156° C. at 0.05 mm Hg.

Workup

  1. temperaturethen refluxed for 24 hours
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated
  4. distillationthen distilled under reduced pressure

Sources & evidence

ORD record
ord-2c127f21a5014dcbba187fdf4486f427
Source dataset
uspto-grants-1981_07
Patent number
US04277498

Reaction notes

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