反应详情

A solution of 2-benzylamino-N-(1,1-dimethylhexyl)acetamide (15.8 g, 57 m mol) in acetic acid (160 ml) was hydrogenated over 10% palladium on charcoal (3.16 g) for 2 hours at atmospheric pressure and 80° C. The mixture was filtered and the filtrate evaporated to a viscous liquid (15 g). This was dissolved in water (40 ml), basified with 10 N sodium hydroxide solution and extracted with ether (3×50 ml). The combined extracts were dried over magnesium sulphate then evaporated and distilled to give 2-amino-N-(1,1-dimethylhexyl)acetamide as a colourless oil, b.p. 92°-94° C. at 0.1 mm Hg.

1. filtrationThe mixture was filtered
2. customthe filtrate evaporated to a viscous liquid (15 g)
3. dissolutionThis was dissolved in water (40 ml)
4. extractionextracted with ether (3×50 ml)
5. dry with materialThe combined extracts were dried over magnesium sulphate
6. customthen evaporated
7. distillationdistilled