Acetonitrile → HCID 53971717, compound

HRID 1277576Notes

Reaction equation

HRID 1277576 reaction equation
[CH3:1][C:2]([OH:10])([CH2:4][CH2:5][CH2:6][C:7](=O)[CH3:8])[CH3:3].[OH-].[K+].[C:13](#[N:15])[CH3:14]>>[CH3:8][C:7]1([CH2:14][C:13]#[N:15])[CH2:6][CH2:5][CH2:4][C:2]([CH3:1])([CH3:3])[O:10]1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 14797Potassium HydroxideHCID 787626-Hydroxy-6-methylheptan-2-one

Product 1

HCID 53971717HCID 53971717, compound

Procedure

The distillation residue of the second reaction is again recycled for a third synthesis after adding a further 122.7 g of 94.5% 2-methyl-heptan-2-ol-6-one (0.80525 moles), 5.2853 g of 86% KOH and acetonitrile in the usual ratio. After the reaction, distillation gives 82.0 g of 2,6,6-trimethyl-2-cyanomethyltetrahydropyran (0.49099 moles) in the distillate, together with the unconverted hydroxyketone.

Workup

  1. customThe distillation residue of the second reaction
  2. customis again recycled for a third synthesis
  3. customAfter the reaction, distillation

Sources & evidence

ORD record
ord-268c091508c74b48a1ba7e4d406dab9c
Source dataset
uspto-grants-1981_07
Patent number
US04278602

Reaction notes

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