Methanol → HCID 178518978, compound

Participants

Reaction Steps

To a solution of 3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridinium bromide (77 mg; 0.35 mmol) in water (0.6 ml) was added a solution of triethylamine (39 mg; 0.39 mmol) in ethanol (0.6 ml). The mixture was left at 25° C. for 2 hours. Ia (42 mg; 86%) was isolated as colourless crystals, m.p. 242°-244° C. (decomp.). IR (KBr): 3700-2900 (s), 2900-1900 (several bands, m-s), 1670 (s), 1625 (m) cm-1. UV [methanol (log ε)]: 212 (3.64) nm. pKA values (H2O, 25° C.): 4.44±0.03, 8.48±0.04.

Provenance & Evidence