Ammonia → HCID 23453200, compound

HRID 1277655Notes

Reaction equation

HRID 1277655 reaction equation
C[O:2][C:3](=O)[CH2:4][N:5]1[C:9]([Cl:10])=[CH:8][CH:7]=[C:6]1[Cl:11].[NH3:13]>CCOCC>[Cl:11][C:6]1[N:5]([CH2:4][C:3]([NH2:13])=[O:2])[C:9]([Cl:10])=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 23453203HCID 23453203, compound

Product 1

HCID 23453200HCID 23453200, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of methyl(2,5-dichloro-1H-pyrrol-1-yl)acetate (0.5 g), in ether (3 cm3), and concentrated aqueous ammonia solution (3 cm3) was stirred at room temperature overnight in a stoppered flask. The precipitated crystalline product was collected by filtration and washed with ether to give 0.07 g of title compound. The ethereal washings were dried and evaporated. The crystalline residue was triturated with diisopropyl ether to give a further 0.13 g of title compound, m.p. 183°-4° C.

Workup

  1. filtrationThe precipitated crystalline product was collected by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-3835336d9a7647988cdb42d926481c09
Source dataset
uspto-grants-1981_07
Patent number
US04278685

Reaction notes

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