5-Chloro-2-methoxybenzoyl chloride → HCID 23453068, compound

HRID 1277672Notes

Reaction equation

HRID 1277672 reaction equation
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:18])([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][CH:6]=1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25](Cl)=[O:26]>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25]([NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:17])([CH3:18])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][CH:6]=1)=[O:26].[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24]([CH:28]=1)[C:25]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]([CH3:17])([CH3:18])[C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1)=[O:26]

Participants

4

Reactant 2

HCID 123841765-Chloro-2-methoxybenzoyl chlorideHCID 20463387HCID 20463387, compound

Product 2

HCID 23453068HCID 23453068, compoundHCID 23453108HCID 23453108, compound

Procedure

In an analogous manner, by the reaction of ethyl 2-[4-(2-aminoethyl)-phenyl]-2-methylpropionate hydrochloride with 5-chloro-2-methoxybenzoyl chloride, there is obtained, via ethyl 2-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-2-methylpropionate (oil), 2-{4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenyl}-2-methylpropionic acid; m.p. 149°-150° C., after recrystallization from glacial acetic acid.

Sources & evidence

ORD record
ord-6e9992383d214308a373e0b01ab9407a
Source dataset
uspto-grants-1981_07
Patent number
US04278680

Reaction notes

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