HRID1277677

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12863246

Benzoyl chloride, 5-chloro-2-(2-methoxyethoxy)-

C10H10Cl2O3

HCID20463406

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C(C)c1ccc(CCNC(=O)c2cc(Cl)ccc2OCCOC)cc1

HCID23453031

未命名化合物

结构：COCCOc1ccc(Cl)cc1C(=O)NCCc1ccc(C(C)C(=O)O)cc1

HCID23453067

未命名化合物

PROCEDURE

实验过程

In a manner analogous to that described in Example 11, by the reaction of ethyl 2-[4-(2-aminoethyl)-phenyl]-propionate hydrochloride with 5-chloro-2-(2-methoxyethoxy)-benzoyl chloride (m.p. 49°-51° C.), there is obtained, via ethyl 2-{4-[2-(5-chloro-2-(2-methoxyethoxy)-benzamido)-ethyl]-phenyl}-propionate (oil), 2-{4-[2-(5-chloro-2-(2-methoxyethoxy)-benzamido)-ethyl]-phenyl}-propionic acid; m.p. 94°-96° C., after recrystallization from isopropanol/water.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2bdadab04d1941c6852d5194a7308256
来源数据集: uspto-grants-1981_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04278680
来源说明: uspto-grants-1981_07

反应 SMILES

Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][CH:6]=1.[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([O:28][CH2:29][CH2:30][O:31][CH3:32])=[C:23]([CH:27]=1)[C:24](Cl)=[O:25]>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([O:28][CH2:29][CH2:30][O:31][CH3:32])=[C:23]([CH:27]=1)[C:24]([NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH3:17])[C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:7][CH:6]=1)=[O:25].[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([O:28][CH2:29][CH2:30][O:31][CH3:32])=[C:23]([CH:27]=1)[C:24]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]([CH3:17])[C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1)=[O:25]