HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Phenylbutyric Acid → 2-(4-Chloromethylphenyl)-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Phenylbutyric Acid | HCID 7012 | — |
| Reactant | Methanone hydrochloride | HCID 19933572 | — |
| Reactant | 2-{4-[2-(5-Chloro-2-methoxybenzamido)-ethyl]-phenyl}-butyric acid | HCID 23453107 | — |
| Product | 2-(4-Chloromethylphenyl)-butyric acid | HCID 20447513 | — |
Reaction Steps
The 2-[4-(2-aminoethyl)-phenyl]-butyric acid hydrochloride used as starting material is prepared in the following manner: 2-phenylbutyric acid is reacted with paraformaldehyde/hydrochloric acid to give 2-(4-chloromethylphenyl)-butyric acid (b.p. 173°-176° C./0.1 mm Hg). By the reaction thereof with potassium cyanide, there is obtained 2-(4-cyanomethylphenyl)-butyric acid (oil) which, after catalytic hydrogenation, gives 2-[4-(2-aminoethyl)-phenyl]-butyric acid hydrochloride; m.p. 128°-130° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04278680 |
| Source dataset | uspto-grants-1981_07 |
| ORD ID | ord-f2b5760ef47046c1874f2c1f50f95b95 |
| Source note | uspto-grants-1981_07 |