3-(2-Chloroethoxy)-2-ethylacrylic acid methyl ester → 3-(2-Chloroethoxy)-2-ethylpropionic acid methyl ester

HRID 1277742노트

반응식

HRID 1277742 반응식
[CH3:1][O:2][C:3](=[O:12])[C:4]([CH2:10][CH3:11])=[CH:5][O:6][CH2:7][CH2:8][Cl:9].[H][H]>CO.[C].[Pd]>[CH3:1][O:2][C:3](=[O:12])[CH:4]([CH2:10][CH3:11])[CH2:5][O:6][CH2:7][CH2:8][Cl:9]

참가 물질

5

반응물 2

HCID 537981423-(2-Chloroethoxy)-2-ethylacrylic acid methyl esterHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 542326673-(2-Chloroethoxy)-2-ethylpropionic acid methyl ester수율 87%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

346.8 g 3-(2-Chloroethoxy)-2-ethyl-acrylic acid methyl ester was hydrogenated in 1200 ml methanol in the presence of 27 g 5% palladium-carbon catalyst at atmospheric pressure. The amount of hydrogen required to saturate the double bond was absorbed within approximately 90-120 minutes, whereupon the catalyst was filtered off, and the filtrate was partly evaporated. The residue was distilled in a vacuum to produce 305 g 3-(2-chloroethoxy)-2-ethyl-propionic acid methyl ester (87% yield) boiling at 110°-112° C./14 torr.

후처리

  1. concentrationto saturate the double bond
  2. customwas absorbed within approximately 90-120 minutes, whereupon the catalyst
  3. filtrationwas filtered off
  4. customthe filtrate was partly evaporated
  5. distillationThe residue was distilled in a vacuum

출처 및 근거

ORD 기록
ord-16b67872444e4da083a2051149c830f8
출처 데이터셋
uspto-grants-1981_07
특허 번호
US04278808

반응 노트

불러오는 중…