Pyridine → HCID 54495907, compound

HRID 1277835Notes

Reaction equation

HRID 1277835 reaction equation
[CH2:1]([C:6]1[CH:7]=[C:8]([CH:28]=[CH:29][CH:30]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13](C2C=CC=CC=2N)=[CH:12][C:11]=1[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:2][CH2:3][CH2:4][CH3:5].Cl[C:32]([O:34][CH2:35][CH3:36])=[O:33].[N:37]1[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>>[CH2:1]([C:6]1[CH:7]=[C:8]([CH:28]=[CH:29][CH:30]=1)[O:9][C:39]1[C:40]([CH2:27][CH2:26][CH2:25][CH2:24][CH3:23])=[C:41]([CH2:7][CH2:8][CH2:28][CH2:29][CH3:30])[C:42]([NH:37][C:32](=[O:33])[O:34][CH2:35][CH3:36])=[C:6]([CH2:1][CH2:2][CH2:3][CH2:4][CH3:5])[C:38]=1[CH2:12][CH2:11][CH2:10][CH2:15][CH3:14])[CH2:2][CH2:3][CH2:4][CH3:5].[CH2:1]([C:6]1[CH:7]=[C:8]([CH:28]=[CH:29][CH:30]=1)[O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:37][C:32](=[O:33])[O:34][CH2:35][CH3:36])=[CH:12][C:11]=1[CH2:23][CH2:24][CH2:25][CH2:26][CH3:27])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 23451844HCID 23451844, compound

Product 2

HCID 54495907HCID 54495907, compoundHCID 57214149HCID 57214149, compound

Conditions

Temperature
5 °C

Procedure

[4-(3-Pentylphenoxy)-3-pentylphenyl]benzenamine (0.1 mole) and pyridine (50 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and are cooled to about 5° C. Ethyl chloroformate (0.125 mole) is added, with stirring, at about 5° C. Stirring is continued for a period of about 30 minutes at about 5° C., then for an additional 16 hours at room temperature. The mixture is then washed with 2 portions of water (50 ml), dried and the solvent is then removed to yield the desired product ethyl [4-(3-pentylphenoxy)-3-pentylphenyl]carbamate.

Workup

  1. customfitted with a mechanical stirrer
  2. stirringStirring
  3. waitfor an additional 16 hours at room temperature
  4. washThe mixture is then washed with 2 portions of water (50 ml)
  5. customdried
  6. customthe solvent is then removed

Sources & evidence

ORD record
ord-62051c47a52441c5beeaf9cc33133d66
Source dataset
uspto-grants-1981_07
Patent number
US04279637

Reaction notes

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