2,2-Dimethoxyethylmethylamine → HCID 23451803, compound

HRID 1277847Notes

Reaction equation

HRID 1277847 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:17])OCC)=[CH:8][C:7]=1[S:18][CH2:19][CH3:20].[CH3:25][O:26][CH:27]([O:31][CH3:32])[CH2:28][NH:29][CH3:30]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13]([N:29]([CH2:28][CH:27]([O:31][CH3:32])[O:26][CH3:25])[CH3:30])=[O:17])=[CH:8][C:7]=1[S:18][CH2:19][CH3:20]

Participants

4

Reactant 2

HCID 85032,2-DimethoxyethylmethylamineHCID 53706667HCID 53706667, compound

Product 1

HCID 23451803HCID 23451803, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl [4-(3,4-dichlorophenoxy)-3-(ethylthio)phenyl]carbamate (0.1 mole) and toluene (100 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and condenser. N-(2,2-dimethoxyethyl)methanamine (0.15 mole) is added to the vessel and the mixture is refluxed for 16 hours. Solvent is then removed by mild warming under reduced pressure to yield the desired product N-[4-(3,4-dichlorophenoxy)-3-(ethylthio)phenyl]-N'-(2,2-dimethoxyethyl)-N'-methylurea.

Workup

  1. customfitted with a mechanical stirrer
  2. temperaturethe mixture is refluxed for 16 hours
  3. customSolvent is then removed
  4. temperatureby mild warming under reduced pressure

Sources & evidence

ORD record
ord-da7b01bcbfdd4f9ba0b804c3416fecac
Source dataset
uspto-grants-1981_07
Patent number
US04279637

Reaction notes

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