1-Heptanamine → N"-heptylguanidine hydrate

HRID 1277892Notes

Reaction equation

HRID 1277892 reaction equation
[CH2:1]([NH2:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[C:9]([NH:11]C(S)=NCCSCC1[O:19]C(CN(C)C)=CC=1)#[N:10]>>[OH2:19].[CH2:1]([N:8]=[C:9]([NH2:11])[NH2:10])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

3

Reactant 2

HCID 81271-HeptanamineHCID 178483237HCID 178483237, compound

Product 1

HCID 86736194N"-heptylguanidine hydrateYield 132%

Procedure

A mixture of heptylamine (1.15 g) and N-cyano-N'-[2-[[[5-(dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]carbamimidothioic acid (3.12 g) was heated on an oil bath for 12 hr at 100°. The product was chromatographed (silica/methanol) to give N-cyano-N'[2-[[[5-dimethylamino)methyl-2-furanyl]methyl]thio]ethyl]N"-heptylguanidine hydrate (2.31 g) Rf 0.49. Analysis Found: C, 56.99; H, 8.32; N, 17.53. C19H33N5OS.H2O requires: C, 57.43; H, 8.81; N, 17.63%.

Workup

  1. temperaturewas heated on an oil bath for 12 hr at 100°
  2. customThe product was chromatographed (silica/methanol)

Sources & evidence

ORD record
ord-c37e040065f74cd9a590ea67014317b3
Source dataset
uspto-grants-1981_07
Patent number
US04279819

Reaction notes

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